The research-based pharmaceutical industry is one of the key assets of the European economy. For pharmaceutical drugs, the industry is shifting from small molecule technology towards biotechnology, with active pharmaceutical ingredients (API), already accounting for half of the market. Existing API plants in North-West Europe will be exploited to the maximum, focussing on energy and cost reduction with minor investments. Major investments will take place in new state-of-the art biotech plants.
Bilfinger Tebodin follows these market trends and offers specific services to help sustain and improve existing plant, as well as providing capabilities and expertise to design new biotech plants for our clients. With over 100 people involved in pharmaceutical projects over many years, backed up by a sound international network, Bilfinger Tebodin is considered a key player on the European market.
Project: Site master planning & conceptual design pharmaceutical campus
Location: Dakha, Bangladesh
Orion Pharma Ltd, one of the premier pharmaceutical companies of Bangladesh, selected Tebodin to develop a site master plan for a new pharmaceutical campus in the district Mymensingh. Orion Pharma plans to produce 600 different products in 25 dosing forms, including tablets, capsules, ampoules, syrups, ointments, and injections. In a joint effort Tebodin and Ireland-based RKD Architects designed the new campus, which houses five different manufacturing buildings for several processes and products including blood plasma fractionation, aseptic and sterile processes, hormones and contraceptives. In the second phase of the project, Tebodin developed the conceptual design for the various campus buildings.
Project: Fast-track offices and labs
Location: Nijmegen, the Netherlands
Together with several partners, Tebodin designed and built Synthon’s new biopharmaceutical laboratory and office building within just one year. A fully integrated project team took on the challenge by executing the design and construction work in parallel. This unconventional approach combined target costing with full financial transparency. The first architectural sketches were made in March 2010 and the fully furnished laboratories and offices were ready for use on March 31, 2011. Champagne flowed when the project team celebrated the completion of the first facility of Synthon’s master plan. Since then Tebodin has engineered several other projects on the site, including a clean room facility for the production of antibody-drug conjugates.
Project: Turnaround of a pharmaceutical plant
Location: Oss, the Netherlands
Tebodin coordinated a three-week maintance stop of a pharmaceutical plant. The goal of the production stop was to complete several projects to secure future production capacity. This project was remarkable for its fast track preparation of only 2.5 months, including the selection of contractors. Other challenges included the limited space for hundreds of contractors to work in, and the diversity of projects and stakeholders. All of those challenges were met, according to Mr. Robert Dam of MSD: ‘It looks like we’ve succeeded together.
Project: Bioprocess Pilot Facility (BPF)
Location: Delft, the Netherlands
The BPF in Delft, the Netherlands, is a joint venture company of industrial partners and the TU Delft for the development of new sustainable production processes. The facility has been specially designed to enable the transition from laboratory to production on an industrial scale. Tebodin was commissioned to do the detailed design for tender and construction, procurement and construction management (EPCm).
DMV Fonterra Excipients
Project: DMV Fonterra Excipients
Location: Foxhol, the Netherlands
DMV Fonterra Excipients produces excipients: inactive substances used as a carrier for the active ingredients in medication. Tebodin was asked for the detailed engineering, procurement and construction management services (EPCm) for the expansion of an existing excipients manufacturing plant. Tebodin performed a pre-HAZOP study to assess the safety risks, which were subsequently reviewed during each design stage. The installation was designed and fully built according EHEDG guidelines with additional HACCP and validation procedures.
Project: Modernization of Animal Health Facility
Location: Burgwedel, Germany
Minimal production loss MSD with ‘storyboard method’
MSD decided to modernize its Animal Health facility in Burgwedel, Germany and started the so-called ZGI project (Zoning & GMP Improvement) in 2013. The project was challenged to minimize the production loss during the construction activities to the absolute minimum. After finalization of the basic engineering in 2015, Tebodin and Bilfinger Bauperformance were awarded as the EPCm contractor. The project has as target to have the production facility upgraded by October 2017. The ‘storyboard method’ resulted in optimal communication between all stakeholders. Good, clear and understandable communication and the creation of one multidisciplinary team is the fundament to success.
How Tebodin helps Pharma clients to achieve their goals
Jan Vermetten, Business Developer at Tebodin, is interviewed about the trends Tebodin notices in the pharmaceutical industry. He takes us along the various client’s questions and the diverse projects derived from these trends. From Synthon to MSD, for every client we find a solution that best fits their needs.
Watch the video below to learn how.